Cockayne Syndrome Linked to Elevated R-Loops Induced by Stalled RNA Polymerase II during Transcription Elongation
Abstract Mutations in the Cockayne Syndrome group B (CSB) gene cause skittles ornament cancer in mice, but premature aging and severe neurodevelopmental defects in humans.CSB, a member of the SWI/SNF family of chromatin remodelers, plays diverse roles in regulating gene expression and transcription-coupled nucleotide excision repair (TC-NER); howev