COCKAYNE SYNDROME LINKED TO ELEVATED R-LOOPS INDUCED BY STALLED RNA POLYMERASE II DURING TRANSCRIPTION ELONGATION

Cockayne Syndrome Linked to Elevated R-Loops Induced by Stalled RNA Polymerase II during Transcription Elongation

Abstract Mutations in the Cockayne Syndrome group B (CSB) gene cause skittles ornament cancer in mice, but premature aging and severe neurodevelopmental defects in humans.CSB, a member of the SWI/SNF family of chromatin remodelers, plays diverse roles in regulating gene expression and transcription-coupled nucleotide excision repair (TC-NER); howev

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The past and future of peri-operative interventions to reduce arthrogenic quadriceps muscle inhibition after total knee arthroplasty: A narrative review

Total knee arthroplasty (TKA) improves patient-reported function by alleviating joint pain, however the surgical trauma exacerbates already impaired muscle function, which leads to further muscle weakness and disability after surgery.This early postoperative strength loss indicates a massive neural inhibition and is primarily driven by a skittles o

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